complex models of human physiology, including cell
proliferation, function, migration/invasion and phenotypic
expression, require cytokine
and metabolic soluble factor exchange from one cell type to
complexity is achieved in
vitro by co-culturing two or more different cell types.
many co-culture applications, mixed co-culture (two or more
cell types cultured in the same chamber) has significant
drawbacks, including population ratio imbalance over time due
to differing proliferation rates and the challenges of
downstream isolation and characterization of the target cell type of interest.
solution is segregated co-culture, in which two cell
types are in biochemical communication but remain physically
power of segregated co-culture to build complexity into
biological models and biomanufacturing is enormous but has
been largely inaccessible due to technical challenges.
KIYATEC’s 3DKUBE™ technology platform unlocks the
power of segregated co-culture in perfused 3D cell culture.